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| # | Club | W–L–D | P | W | L | D | % | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MelbourneMelbourne | 17–4–1 | 22 | 17 | 4 | 1 | 130.8 | 70 | |
| 2 | Port AdelaidePort | 17–5–0 | 22 | 17 | 5 | 0 | 126.3 | 68 | |
| 3 | Geelong CatsGeelong | 16–6–0 | 22 | 16 | 6 | 0 | 126.7 | 64 | |
| 4 | Brisbane LionsBrisbane | 15–7–0 | 22 | 15 | 7 | 0 | 133.3 | 60 | |
| 5 | Western BulldogsBulldogs | 15–7–0 | 22 | 15 | 7 | 0 | 132.8 | 60 | |
| 6 | Sydney SwansSydney | 15–7–0 | 22 | 15 | 7 | 0 | 119.9 | 60 | |
| 7 | GWS GiantsGWS | 11–10–1 | 22 | 11 | 10 | 1 | 99.7 | 46 | |
| 8 | EssendonEssendon | 11–11–0 | 22 | 11 | 11 | 0 | 109.1 | 44 | |
| 9 | West Coast EaglesWest Coast | 10–12–0 | 22 | 10 | 12 | 0 | 93.2 | 40 | |
| 10 | St KildaSt Kilda | 10–12–0 | 22 | 10 | 12 | 0 | 91.5 | 40 | |
| 11 | FremantleFremantle | 10–12–0 | 22 | 10 | 12 | 0 | 86.5 | 40 | |
| 12 | RichmondRichmond | 9–12–1 | 22 | 9 | 12 | 1 | 97.9 | 38 | |
| 13 | CarltonCarlton | 8–14–0 | 22 | 8 | 14 | 0 | 88.5 | 32 | |
| 14 | HawthornHawthorn | 7–13–2 | 22 | 7 | 13 | 2 | 85.2 | 32 | |
| 15 | Adelaide CrowsAdelaide | 7–15–0 | 22 | 7 | 15 | 0 | 82.0 | 28 | |
| 16 | Gold Coast SunsGold Coast | 7–15–0 | 22 | 7 | 15 | 0 | 76.8 | 28 | |
| 17 | CollingwoodCollingwood | 6–16–0 | 22 | 6 | 16 | 0 | 85.6 | 24 | |
| 18 | North MelbourneNorth | 4–17–1 | 22 | 4 | 17 | 1 | 70.3 | 18 |
Melbourne won the 2021 premiership, beating Western Bulldogs in the grand final, 21.14 (140) to 10.6 (66) at Optus Stadium.
Melbourne were minor premiers with 17 wins and 1 draw from 22 games.
North Melbourne finished last with 4 wins and 1 draw.
Every game this season has a match page with player stats.